PharmPK Discussion - Glass electrode calibration

• On 25 Nov 2011 at 07:45:54, palacharla raghava chowdary (raghavchowdary.-at-.gmail.com) sent the message
  

  
  Dear All,
  
  Can anybody help me in determining the parameters from the blank
  titration data using four plus technique (weighted non-linear least
  squares) ??
  
   pHm  =  a + S pcH + jH * [H+] + jOH * [H+]
  
   I have the data from blank titration where x is volume of titrant
  (NaOH) added and Y is pH at that point.
  
   But the equation does not contain any X term to fit the data.
  
       Below is the blank titration data
  
  pH  Vol of NaOH added cumulative
  3.01  0.0000
  3.04  0.0020
  3.11  0.0050
  3.19  0.0090
  3.29  0.0120
  3.41  0.0150
  3.56  0.0180
  3.76  0.0208
  4.03  0.0228
  4.44  0.0243
  4.93  0.0245
  7.73  0.0260
  8.30  0.0260
  8.57  0.0260
  8.74  0.0260
  8.88  0.0265
  8.99  0.0265
  9.08  0.0265
  9.17  0.0270
  9.25  0.0270
  9.32  0.0275
  9.45  0.0275
  9.57  0.0280
  9.72  0.0285
  9.97  0.0305
  10.20  0.0325
  10.40  0.0355
  10.58  0.0395
  10.71  0.0435
  10.82  0.0485
  10.91  0.0535
  10.99  0.0585
  11.04  0.0635
  11.10  0.0685
  11.15  0.0735
  
  

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