PharmPK Discussion - Higher dose with lower toxicity

• On 18 Jun 2011 at 13:26:52, Jack Wang (wxinting1986.at.gmail.com) sent the message
  

  
  Hi All,
  
  I am testing the pancreas toxicity of a compound in rats. The lower dose  (20mg/Kg) have a greater weight loss, along with increased food and  water intake, which is an indication of diabetes, while the higher dose  (100mg/Kg) didn't show such a sign. Oral glucose tolerance test  confirmed this with a much higher plasma glucose from the lower dose.
  I have suspected a CPY450 enzyme induction by the higher dose, because  this compound have a enzyme induction ability. Also, there's a  possibility that this compound induced the ABC transporter in pancreas  and resulted in a lower pancreas drug concentration. Is there any  literature discussing about this issue, or have anyone met such  phenomenon before?
  
  Thanks a lot.
  
  -- Yours, Xinting Wang
  Email: wxinting1986.aaa.gmail.com
  Key Laboratory of Drug Metabolism & Pharmacokinetics
  China Pharmaceutical University
  
  

  Back to the Top

Copyright 1995-2011 David W. A. Bourne (david@boomer.org)