Back to the Top
I am testing the pancreas toxicity of a compound in rats. The lower dose (20mg/Kg) have a greater weight loss, along with increased food and water intake, which is an indication of diabetes, while the higher dose (100mg/Kg) didn't show such a sign. Oral glucose tolerance test confirmed this with a much higher plasma glucose from the lower dose.
I have suspected a CPY450 enzyme induction by the higher dose, because this compound have a enzyme induction ability. Also, there's a possibility that this compound induced the ABC transporter in pancreas and resulted in a lower pancreas drug concentration. Is there any literature discussing about this issue, or have anyone met such phenomenon before?
Thanks a lot.
-- Yours, Xinting Wang
Key Laboratory of Drug Metabolism & Pharmacokinetics
China Pharmaceutical University
Want to post a follow-up message on this topic?
If this link does not work with your browser send a follow-up message to PharmPK@boomer.org with "Higher dose with lower toxicity" as the subject
Support PharmPK by using the
Copyright 1995-2011 David W. A. Bourne (firstname.lastname@example.org)