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I have question about the normalization of AUC and Cmax.
Patients who involved into clinical trial usually have big variation of body weight and the dosage. I read some references. The author usually normalized AUC and Cmax by using dosage and body weight or both of them, such as (AUC/Dosage) or (AUC/Dosage/Weight)
I can understand the normalization of AUC by using dosage. But why AUC can be normalized by using body weight? Does the Cmax really need to be normalized?
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