PharmPK Discussion - Initial estimates generated by Curve stripping in PK Compartmental modeling

• On 16 Nov 2011 at 20:51:42, Harish Kaushik Kotakonda (kaushikkotakonda.at.gmail.com) sent the message
  

  
  Dear All,
  I have a very basic question with regards to use of curve stripping for
  determining initial estimates in compartmental modelling following IV
  bolus and oral dose administration.
  I know that curve stripping is done in case of single dosing situations
  for generating initial estimates then what about multiple doses cases
  how do we input the initial estimates while dosing compartmental
  analysis?
  If curve stripping is done for multiple dose cases also then How does
  one do curve stripping in case of Multiple dose scenario, which dose has
  to be entered in WINNONLIN for curve stripping
  In case of unequal doses dosed at regular intervals in that scenario
  which dose do we consider for curve stripping? should we consider
  initial dose or last dose for curvestripping?
  In general what is the frequency of its usage in frequent compartmental
  analysis by PK community in their day to day analysis
  Did anyone compare the final estimates generated when initial estimate
  are generated by winnonlin and user defined estimates, which one worked
  better?
  I would appreciate comments from our esteemed PK community
  
  Regards,
  K.Harish Kaushik
  Systems Engineer
  PK/PD Software development team
  TCS Hyderabad
  India
  
  

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