PharmPK Discussion - Literature reference for Protein Binding in Renal Impairment-Role of Endogenous Factors

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On 1 Mar 2011 at 15:54:22, David Benziger (David.Benziger.at.cubist.com) sent the message


Does anyone have a reference(s) that demonstrate lower protein binding  in the renally impaired caused by buildup of endogenous "waste  materials"?

I know renal impairment is often accompanied by decreases in albumin and  other proteins,  but I'm interested to see if increases in BUN,  creatinine, or other components can alter protein binding in these  patients.

Thanks - Dave

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