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Dear All Pharmacokineticists and Statiticians
May I ask you a one more flavor? I believes that clinical trial which is
a cross over study in a large number of subjects (let say more than 30
subjects), it is impossible that to conduct the study for all subjects
in one period at the same time. If you want to do that you need to have
a big facility with plenty of enough beds to run the study. Am I
correct? I also remember that we did many large number of subject study
and we had to divide the subject in a lot which we can have enough beds
to facilitate the study. The time to finish each lot of subjects did not
take too long (let say less than a month). On you opinion and in
practice, do we need to show the multi group effect in mixed effect
model or not? Or, what should we do for this case? Would you mind
helping me answer this question? Thank you a lot in advance.
Best regards
Korbtham Sathirakul
Department of Pharmacy, Faculty of Pharmacy
Mahidol University
Bangkok, Thailand
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Hi Korbtham,
Yes, you need to add it to your anova model. If the dosing intervals are similar to all
the subjects then there should not be any difference because of the subjects.
But, still you need to add group as error term to check the effect.
Regads,
Venkatesan
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