PharmPK Discussion - Nicotine clinical trial

• On 28 Aug 2011 at 19:34:41, jacob george (jacob0375.-at-.gmail.com) sent the message
  

  
  Dear All,
  
  We are trying to conduct a clinical trial for nicotine in human
  volunteers could anyone guide us regarding the precautions to be taken
  during the same as the compound is omnipresent,As per the report from
  our bioanalysis section there is interference in blank matrix taken from
  Normal non-smoking volunteers.Expecting your valuable inputs.
  
  Thanks In advance
  Dr Jacob.
  
  

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• On 30 Aug 2011 at 10:31:25, ratnakar (ratnakarj.-a-.siteclabs.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Dr. Jacob,
  What you can do is, take blank matrix from nonsmokers volunteers with strict
  restriction of for 3-4 days in-house with controlled access. Also all staff
  should have to follow strict restriction for usage of nicotine.
  
  Best Regards,
  
  Ratnakar
  
  

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• On 31 Aug 2011 at 12:57:39, Christine Brandquist (cbrandquist.-a-.yahoo.com) sent the message
  

  
  Dear Dr Jacob,
  
  Additionally, during sample processing and bioanalytical analysis, only
  allow non-smokers from the clinic and the lab to handle the samples.  It
  is also helpful to prewash the transfer tubes with methanol.
  
  Best of Luck,
  Christine
  
  

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