PharmPK Discussion - P-gp modulation study

• On 27 Mar 2011 at 13:30:51, Rahul Vats (rahulvats1983.-a-.gmail.com) sent the message
  

  
  Dear all,
  
  As per your expert comments, i re-conducted  P-gp modulation study and  changed aggressive
  formulation (containing PEG 400,Ethanol and water) to  mild suspension (0.5% MC+Tween 80).
  As a result i am getting clear drug  drug interaction now. AUC is increasing by 3 folds as
  compared to no  change in aggressive formulation which may indicate impact of soluble
  formulation (highly permeable drug) on under predictable efflux property  of P-gp.
  But basic problem is remain same.
  1) I am not able to calculate other parameters of pharmacokinetics  (change in clearance,
  t1/2, Vd ) as time Vs Plasma concentration graph  is some what plateau (could be due to
  precipitation of formulation in  GIT and was not observed in aggressive formulation)
  2) What strategy in terms of formulation (suspension formulation or  soluble formulation
  )should i use to carry out in-vitro DDI (P-gp based  models) studies as i am worried about
  the same result (under  predictability of power of P-gp efflux while selecting soluble
  formulation) of not getting any interaction?
  
  I would like to thank once again to all of you for giving such a  wonderful comments. --
  Regards,
  
  Rahul Vats
  BITS-Pilani, Hyderabad Campus,
  
  

  Back to the Top

Copyright 1995-2011 David W. A. Bourne (david@boomer.org)