PharmPK Discussion - Paracetamol PK

• On 9 Sep 2011 at 05:51:35, chandramouli Radhakrishnan (rcmoulirc.at.gmail.com) sent the message
  

  
  Hi I am trying to look at pk of paracetamol in healthy population .. and
  there are quite a few paper available, can someone suggest me a good one
  
  please ?
  
  

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• On 9 Sep 2011 at 16:40:16, "J.H. Proost" (j.h.proost.at.rug.nl) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Chandramouli Radhakrishnan,
  
  A list of references on paracetamol (acetaminophen) PK in humans:
  
  1.         Tan, C. and A. Graudins, Comparative pharmacokinetics of
  Panadol Extend and immediate-release paracetamol in a simulated overdose
  model. Emergency Medicine Australasia, 2006. 18(4): 398-403.
  2.         Douglas, D.R., J.B. Sholal, and M.J. Smilkstein, A
  Pharmacokinetic Comparison of Acetaminophen Products (Tylenol Extended
  Relief vs Regular Tylenol). Academic Emergency Medicine, 1996. 3(8):
  740-744.
  3.         Portoles, A., et al., A new high-absorption-rate Paracetamol
  500-mg formulation: a comparative bioavailability study in healthy
  volunteers. Current Therapeutic Research, 2003. 64(7): 401-411.
  4.         Rygnestad, T., K. Zahlsen, and F.A. Samdal, Absorption of
  effervescent paracetamol tablets relative to ordinary paracetamol
  tablets in healthy volunteers. European Journal of Clinical
  Pharmacology, 2000. 56(2): 141-143.
  5.         Bannwarth, B., et al., Single and multiple dose
  pharmacokinetics of acetaminophen (paracetamol) in polymedicated very
  old patients with rheumatic pain. The Journal of Rheumatology, 2001.
  28(1): 182-184.
  6.         Yin, O.Q.P., et al., Pharmacokinetics of acetaminophen in
  Hong Kong Chinese subjects. International Journal of Pharmaceutics,
  2001. 222(2): 305-308.
  7.         Critchley, J.A.J.H., et al., Differences in the
  single-oral-dose pharmacokinetics and urinary excretion of paracetamol
  and its conjugates between Hong Kong Chinese and Caucasian subjects.
  Journal of Clinical Pharmacy and Therapeutics, 2005. 30(2): 179-184.
  8.         Borin, M.T. and J.W. Ayres, Single dose bioavailability of
  acetaminophen following oral administration. International Journal of
  Pharmaceutics, 1989. 54(3): 199-209.
  9.         Kamali, F., The effect of probenecid on paracetamol
  metabolism and pharmacokinetics. European Journal of Clinical
  Pharmacology, 1993. 45(6): 551-553.
  
  It is difficult to say which one is good; this is of course also
  dependent on what you want to know.
  
  best regards,
  
  Hans Proost
  
  Johannes H. Proost
  Dept. of Pharmacokinetics, Toxicology and Targeting
  University Centre for Pharmacy
  Antonius Deusinglaan 1
  9713 AV Groningen, The Netherlands
  
  

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