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Hi I am trying to look at pk of paracetamol in healthy population .. and
there are quite a few paper available, can someone suggest me a good one
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Dear Chandramouli Radhakrishnan,
A list of references on paracetamol (acetaminophen) PK in humans:
1. Tan, C. and A. Graudins, Comparative pharmacokinetics of
Panadol Extend and immediate-release paracetamol in a simulated overdose
model. Emergency Medicine Australasia, 2006. 18(4): 398-403.
2. Douglas, D.R., J.B. Sholal, and M.J. Smilkstein, A
Pharmacokinetic Comparison of Acetaminophen Products (Tylenol Extended
Relief vs Regular Tylenol). Academic Emergency Medicine, 1996. 3(8):
3. Portoles, A., et al., A new high-absorption-rate Paracetamol
500-mg formulation: a comparative bioavailability study in healthy
volunteers. Current Therapeutic Research, 2003. 64(7): 401-411.
4. Rygnestad, T., K. Zahlsen, and F.A. Samdal, Absorption of
effervescent paracetamol tablets relative to ordinary paracetamol
tablets in healthy volunteers. European Journal of Clinical
Pharmacology, 2000. 56(2): 141-143.
5. Bannwarth, B., et al., Single and multiple dose
pharmacokinetics of acetaminophen (paracetamol) in polymedicated very
old patients with rheumatic pain. The Journal of Rheumatology, 2001.
6. Yin, O.Q.P., et al., Pharmacokinetics of acetaminophen in
Hong Kong Chinese subjects. International Journal of Pharmaceutics,
2001. 222(2): 305-308.
7. Critchley, J.A.J.H., et al., Differences in the
single-oral-dose pharmacokinetics and urinary excretion of paracetamol
and its conjugates between Hong Kong Chinese and Caucasian subjects.
Journal of Clinical Pharmacy and Therapeutics, 2005. 30(2): 179-184.
8. Borin, M.T. and J.W. Ayres, Single dose bioavailability of
acetaminophen following oral administration. International Journal of
Pharmaceutics, 1989. 54(3): 199-209.
9. Kamali, F., The effect of probenecid on paracetamol
metabolism and pharmacokinetics. European Journal of Clinical
Pharmacology, 1993. 45(6): 551-553.
It is difficult to say which one is good; this is of course also
dependent on what you want to know.
Johannes H. Proost
Dept. of Pharmacokinetics, Toxicology and Targeting
University Centre for Pharmacy
Antonius Deusinglaan 1
9713 AV Groningen, The Netherlands
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