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We prepared the hydrotropic complex of calcium channel blocker using nicotinamide as hydrotrope at pH 4.5. In vitro data showed that there is the improvement of the solubility of drug in hydrotropic complex compare to the plain drugs.
We carried out the in-vivo pk studies in rats.
We observed that there is not at all drug is absorbing at the site of action. We could not able to get the PK profile of drug. All concentration are below quantification limit.
Before carrying out the studies, we did the assay of the drug in complex. According to assay the dose of the drug is calculated as same of plain drug.
Kindly focus on the issues.
Thanking you in advanced.
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