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I have some raw plasma concentration datas about drug D and S (18 healthy beagle dogs following a 30 min intravenous (i.v.) infusion of 20, 40 and 80 mg/kg body weight) as an attachment [attachment removed - db]. And the pharmacokinetic parameters have been calculated by DAS 2.1.1 software, which indicated that there is a 3-compartment open model. Is there anybody who can help me to re-calculated the pharmacokinetic parameters of D and S by WinNolin software via compartmental and noncompartmental analyses? Meanwihle, I just want to appeal for somebody who can deal with that experimental data by NONMEM software to disscuss the influence of sex and its mean population estimated parameters.
Thank you very much! If there is somebody who want to calculate the pharmacokinetic parameters using DAS software, please connect with me.
I am looking forward to hearing from you!
Shenyang Pharmaceutical University
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