PharmPK Discussion - SDPK question

• On 3 Aug 2011 at 18:35:23, Yongguo Li (yongguoli.aaa.yahoo.com) sent the message
  

  
  Dear team,
  
  I am quite confusion for one SDPK results that got it recently.
  
  Mice SDPK,
  dosing routine: iv (2 mg/kg), po (20 mg/kg), ip (20 mg/kg)
  Results: iv showed a lttle but not large exposure.
  
          po showed very poor plasma exposure, F% near 2%
          ip obtained very high plasma exposure, F% 240%
  
  Questions: Anybody can help me to explain
  1) Why po exposure so poor, iv not good enough while ip so high.
  2) the reasons of bioavailability (%F) of ip more than 200%
  3) What's the specific PK for ip.
  
  Thanks a lot!
  
  Young
  
  

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