PharmPK Discussion - Solubility of methotrexate

• On 13 Jan 2011 at 23:10:14, nil pk (nilpharmapk.aaa.gmail.com) sent the message
  

  
  Dear All
  Can any one tell solubility of methotrexate in organic solvent ? DMSO  and DMF it is soluble. Literature says that it is soluble in acetone and  dichloromethane. But we tried but it could not able to soluble. Any one  have best way to solublis will acknowledge.
   Regards
  NIL
  
  

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• On 14 Jan 2011 at 09:32:22, satyajeet narode (satyajeet0407.-a-.gmail.com) sent the message
  

  
  Dear Nil
   Methotrexate is class IV drug in short it is having low solubility and  low permiability. It is practically soluble in Ethanol,Highly soluble in  DMSO and DMF.I would also like to tell you that it is also soluble in  Acetone.
   Kindly check which form you are using for checking solubility whether  crystalline or amorphous.Also note that marketed product of Methotrexate  are salt form of Methotrexate.
   Hope this is useful
   Regards
   Satyajeet
  
  

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• On 17 Jan 2011 at 10:21:57, satyajeet narode (satyajeet0407.-at-.gmail.com) sent the message
  

  
  Dear Nil
   I tried with normal crystalline form of Methotrexate (MTX) it is soluble  in Acetone. Kindly let me know your application area so that I will be  able to suggest some better options.
   For information on crystalline form of MTX kindly find attached article.
   Regards
   Satya
  
  

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• On 19 Jan 2011 at 14:53:28, satyajeet narode (satyajeet0407.aaa.gmail.com) sent the message
  

  
  Dear Nil
   At our lab in BASF India ltd.We tried tried with DMSO,Acetone and DMF.It  is soluble in all three.There are some literature in that DMSO is used  for preparation of nanoparticals.I will suggest to use acetone as it  will easily get evaporated. Also try to use Albumin for preparation of  nanoparticals.
   Hope this will be useful
   Regards
   Satyajeet
  
  

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