PharmPK Discussion - Solution for iv administration of a poorly soluble compound

• On 29 Mar 2011 at 10:05:46, joan hern (joanhc0603.-at-.gmail.com) sent the message
  

  
  Dear all,
   I would like to prepare a solution for iv administration of a poor  soluble compound . I have tried with beta-cyclodextrine withouth  success. Has anyone experienced with gamma-cyclodextrine?. Would it be a  better option than beta-cyclodextrin?
  I would appreciate your comments.
  Thans in adance for all
  joan
  
  

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• On 30 Mar 2011 at 01:18:55, Alec YU (yuhuayu.aaa.vip.sina.com) sent the message
  

  
  Dear Joan
  
  For iv administration of poor soluble drugs, you can try to use some  inorganic solvent, such as PEG100-400. I have tried to use PEG200  before.
  --
  Best Regards, Alec H YU
  
  

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• On 30 Mar 2011 at 10:29:09, (Ttarnowski1.aaa.aol.com) sent the message
  

  
  Dear Joan,
  Regarding choice of beta- versus gamma cyclodextrin (or other  cyclodextrins), it first depends on how well the compound binds into the  central cavity of the specific cyclodextrin.  Gamma cyclodextrin has a  larger cavity and can accommodate larger molecules.  Cyclodextrin  binding affinities tend to be relatively low (e.g., compared to  antibodies), cyclodextrins themselves have specific aqueous  solubilities.  There are also derivatized cyclodextrins that have higher  aqueous solubilities.  The best approach is to obtain samples of cyclodextrins and test them in  vitro.  Note also that use of organic co-solvents with cyclodextrins will  compete with the compound for the cyclodextrin binding site.
   -Tom
   Thomas L. Tarnowski, Ph.D.
  CMC and Bioanalytics
  Department Head, Biopharmaceutical Development
  Elan Pharmaceuticals, Inc.
  800 Gateway Boulevard
  South San Francisco, CA 94080
  thomas.tarnowski.at.elan.com
  
  

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• On 30 Mar 2011 at 12:24:36, kaustuv sahoo (kspharm4u.at.gmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi Joan,
  
  I think you can try with hydroxypropyl beta cyclodextrin, along with
  changing the pH if it does not affect the stability of your drug. Also
  you can try with solvents like PEG 400.
  
  TRY IT.
  
  thanks,
  
  

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