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Raja,
Great question about the differences between non-inferiority and superiority trials. The choice of which trial to run depends upon the hypothesis that you wish to address. You can read more about the differences between non-inferiority, superiority and bioquivalence study designs and the impact on sample size at my blog:
http://wp.me/p1fZzZ-1H
Best of luck!
Nathan Teuscher
blog.learnpkpd.com
www.learnpkpd.com
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