PharmPK Discussion - Using WinNonlin for individual estimates based on pop PK output from NLME

• On 17 Jul 2011 at 13:42:42, "Lisa E. Davis" (l.davis.aaa.usciences.edu) sent the message
  

  
  The following message was posted to: PharmPK
  
  I am having a problem using Phoenix NLME with WinNonlin interface. I used NLME to obtain
  PK estimates for a population set of data. Subjects received different doses daily or q12h
  for up to 6 months and 1-5 samples were drawn at various times over that time period. Most
  would not have reached steady-state. I am trying to estimate the individual PK parameters
  Cmax and AUC using the population values and the individual concentration data with
  WinNonlin.
  1) If I rerun the final population model and sort by ID, I get tv parameters for each
  subject. Can I use those or do I need to work with the population tv values?
  2) With previous versions of WinNonlin I could enter a dosing regimen with multiple doses
  and simulate the concentrations. Since the subjects received a different am and pm dose, I
  can't figure out how to enter the dosing regimens into WinNonlin without typing them all
  out (could be >400 lines of data) whereas with NLME I could use the ADDL input.
  
  Any advice?
  Best regards
  Lisa
  

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• On 20 Jul 2011 at 11:01:41, Simon Davis (Simon.Davis.aaa.certara.com) sent the message
  

  
  Hi Lisa,
  
  I'm not sure for the 1st question how to answer as I guess it depends on what you want to
  use the results for later, i.e. what is your aim - predicting different regimens for those
  individuals or for a typical population?  Are you looking at identifying covariates etc.
  Perhaps in NLME mode you want to use the "add table" button to get "structural parameter
  estimates"
  
  [Image with Check Variables: Ka, V, Ke - db]
  
  This would give you the individual post-hoc estimates
  
    For the second question;
  
  2) With previous versions of WinNonlin I could enter a dosing regimen with multiple doses
  and simulate the concentrations. Since the subjects received a different am and pm dose, I
  can't figure out how to enter the dosing regimens into WinNonlin without typing them all
  out (could be >400 lines of data) whereas with NLME I could use the ADDL input.
  
     I think I need to see your project file to understand your problem better - you could
  either email to support.-a-.pharsight.com, or post it to the user discussion forum;
  www.pharsight.com/extranet (since PharmPK does not permit attachments.  I guess my first
  question would be if you have these 400+ lines of data of different doses somewhere
  already - why don't you import them into phoenix and map them directly rather than
  re-typing them.
  
      Best regards,
                           Simon.
  
  --
  Simon.Davis.-a-.certara.com
  Senior Scientific Consultant
  Pharsight- A Certara(TM) Company
  

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