PharmPK Discussion - Villus blood flow

• On 31 May 2011 at 03:41:09, wangjian (wj801126.at.hotmail.com) sent the message
  

  
  Dear All:
  
        Does anyone can tell me the value of villus blood flow which is  used to calculate the Qgut? Thanks!
  
  Jian
  
  

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• On 31 May 2011 at 08:39:54, David Turner (d.turner.-at-.SIMCYP.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Jian
  
  Please look at the following paper:
  
  Yang, Jamei, Yeo, Tucker, Rostami-Hodjegan (2007) Prediction of  intestinal first-pass metabolism. Curr Drug Metab 8 676-684.
  
  This paper discusses villous blood flow (Qvilli) for an average  (healthy) adult. It is expressed as a proportion of total mesenteric  flow.
  
  Where these blood flows are expressed as a proportion of total cardiac  output this allows (inter-individual) variability in the latter to be  propagated to the former ...
  
  Note that total mesenteric blood flow and hence Qvilli increases in the  fed state.
  
  Regards
  
  David Turner
  Principal Scientist
  Simcyp Limited
  Sheffield, UK
  www.simcyp.com
  
  

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