PharmPK Discussion - BCS with low water solubility

• On 2 Oct 2012 at 08:34:49, "Prof. Dr. Zafar Iqbal" (zafar_iqbal.aaa.upesh.edu.pk) sent the message
  

  
  Dear Colleagues.
  
  If drug have low water solubility and lower absolute bioavailability (F < 0.3),
  then is it possible to place it BCS class IV?
  
  Dr Zafar Iqbal
  

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• On 2 Oct 2012 at 11:59:11, Chris Kemper (chris_kemper.-a-.pharmanavigatorsllc.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dr.Iqbal:
  
  I tend to hesitate using bioavailability as a BCS criteria since it is as
  much a function of formulation as an inherent physical property of the
  compound. Case in point is itraconazole, which is listed as a Class II
  compound. Given the wrong formulation, its absolute bioavailability  is very
  low and, as a compound of very low solubility, would be, I think, wrongly
  classified as Class IV.
  
  Christopher J. Kemper, Ph.D.
  Pharma Navigators, LLC
  DMPK/Bioanalytical Consulting
  Alliance Management/Business Analysis
  
  

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• On 3 Oct 2012 at 09:16:36, Ashok kumar Meena (ashok_meena.-a-.jubilantbiosys.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Dr Zafar Iqbal,
  BCS classification is based on the compound solubility and permeability =
  so we
  should have solubility and permeability data with us to classify the =
  compound.
  This compound shows very low BA so we can say low permeable but there =
  are number
  of other factors responsible for low BA.=20
  
  Regards
  Ashok Meena
  --
  Ashok Kumar Meena
  Pharmaceutical Development, Jubilant Biosys Limited, #96, Industrial =
  Suburb, 2nd
  Stage, Yeshwanthpur
  Bangalore-560022, India=
  
  

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• On 3 Oct 2012 at 20:30:24, R M Rao Kusumanchi (kusumanchis.at.gmail.com) sent the message
  

  
  Dear Dr Zafar Iqbal
  
  If drug dose solubility ratio is less than 250 mL in the entire pH range =
  of 1 to
  7.5 it is considered as Highly soluble and absolute bioavailability is =
  greater
  than 85% is considered to be highly permeable
  
  Thanks and Regards
  
  R M Rao Kusumanchi., M. Pharm
  Sr. Research Associate
  Hetero Drugs Ltd.,
  Hyderabad=
  
  

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• On 3 Oct 2012 at 14:44:07, "rmsampaio2002.-a-.yahoo.com.br" (rmsampaio2002.-at-.yahoo.com.br) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Dr. Zafar Iqbal,=20
  
  there are other reasons to low Bioavailabilitiy. e.g.: Extensive =
  Metabolism.
  
  Then, we can not to affirm 100% that drugs with low water solubility and =
  lower
  bioavailability are class IV.=20
  
  Regards
  
  Enviado por Mauricio Sampaio=
  
  

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• On 4 Oct 2012 at 06:59:15, "Prof. Dr. Zafar Iqbal" (zafar_iqbal.-at-.upesh.edu.pk) sent the message
  

  
  Dear Rao,
  
  On this basis I was looking to keep this compunds in BCS class IV. Thanks for
  help.
  
  Regrads
  Dr Zafar
  
  

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