PharmPK Discussion - Cyclosporine therapeutic range

• On 15 Apr 2012 at 11:40:16, ehab eldesoky (ehegypt.-a-.yahoo.com) sent the message
  

  
  Hi,
  Is there any suggestion for the level and /or therapeutic range of cyclosporine plasma
  concentration when given in patients for autoimmune disorders and not for transplantation?
  What about a trough range: 100-200 ug/ml?
  Ehab
  Professor Ehab S. EL Desoky
  Head,
  Lab of Therapeutic Drug monitoring
  Assiut University Hospital
  Assiut, Egypt
  

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• On 16 Apr 2012 at 07:45:45, DRGUNA SAKARAN (drgunasakaran.-at-.gmail.com) sent the message
  

  
  Dear Mr.Ehab,
  
  The trough levels of Cyclosporine when administered to Rheumatoid Arthritis subjects is in
  the range of 96.4 +/- 37.7 ng/ml.
  The Cmax is 728 +/- 263 ng/ml and AUC 2641 +/- 877ng.hr/ml.
  
  AUC was measured over one dosing interval.
  
  Trough concentration was measured just prior to the morning cyclosporine dose,
  approximately 12 hours after the previous dose.
  
  Reference:
  http://www.pharma.us.novartis.com/product/pi/pdf/neoral.pdf
  
  Dr.S.Gunasakaran, MD
  Head - Clinical Research & Medical Affairs,
  Azidus Clinical Research Organization, India
  
  

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• On 17 Apr 2012 at 12:41:33, ehab eldesoky (ehegypt.at.yahoo.com) sent the message
  

  
  Thanks Dr Gunasakaran.
  
  Can we establish trough level only as a trend of TDM  of cyclosporine in
  autoimmune disorder?
  Does any one have a personal clinical experience as regards this issue  ?
  
  

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