PharmPK Discussion - Effect of alcohol on in vivo bioavailabilty from CR dosage forms

• On 26 Nov 2012 at 20:29:24, (azia_karim.-at-.yahoo.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear All, I would be most grateful if some one could provide me references to
  examining effect of alcohol on the in vitro dissolution and in vivo
  bioavailability of drugs from the controlled-release oral dosage forms.
  
  Thank you for your help.
  
  Aziz Karim
  
  

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• On 26 Nov 2012 at 21:33:51, "Dean W. Knuth" (DeanKnuth.-at-.jasperclinic.biz) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi Aziz - here's one that may help -
  http://jcp.sagepub.com/content/early/2011/05/18/0091270011403740.abstract
  
  ---dean
  
  Dean W. Knuth
  President & CEO
  Jasper Clinical Research & Development, Inc.
  526 Jasper Street
  Kalamazoo MI 49007
  
  

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• On 27 Nov 2012 at 15:22:29, "Sista, Suryanarayana" (Suryanarayana.Sista.-a-.fda.hhs.gov) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Aziz,
  
  Here are a few references:
  --
  J Pain. 2012 Jan;13(1):90-9.
  The effects of ethanol on the bioavailability of oxymorphone extended-release
  tablets and oxymorphone crush-resistant extended-release tablets.
  Fiske WD, Jobes J, Xiang Q, Chang SC, Benedek IH.
  
  Mol Pharm. 2009 Sep-Oct;6(5):1429-40.
  Ethanol-drug absorption interaction: potential for a significant effect on the
  plasma pharmacokinetics of ethanol vulnerable formulations.
  Lennernaes H.
  
  Int J Pharm. 2010 Oct 15;398(1-2):93-6. Epub 2010 Aug 1.
  In vitro dissolution of oral modified-release tablets and capsules in ethanolic
  media.
  Smith AP, Moore TW, Westenberger BJ, Doub WH.
  
  Drug Dev Ind Pharm. 2008 Aug;34(8):885-9.
  Influence of alcohol on the release of tramadol from 24-h controlled-release
  formulations during in vitro dissolution experiments.
  Traynor MJ, Brown MB, Pannala A, Beck P, Martin GP.
  
  Int J Pharm. 2008 Aug 6;360(1-2):171-6. Epub 2008 Apr 30.
  Impairment of the in vitro drug release behaviour of oral modified release
  preparations in the presence of alcohol.
  Fadda HM, Mohamed MA, Basit AW.
  
  Am J Ther. 2009 Nov-Dec;16(6):482-6.
  Effect of ethanol on the release of morphine sulfate from Oramorph SR tablets.
  Barkin RL, Shirazi D, Kinzler E.
  
  Int J Pharm. 2009 Feb 23;368(1-2):72-5. Epub 2008 Oct 15.
  Ethanol effects on drug release from Verapamil Meltrex, an innovative melt
  extruded formulation.
  Roth W, Setnik B, Zietsch M, Burst A, Breitenbach J, Sellers E, Brennan D.
  
  J Pain. 2008 Apr;9(4):330-6. Epub 2008 Jan 16.
  Effect of concomitant ingestion of alcohol on the in vivo pharmacokinetics of
  KADIAN (morphine sulfate extended-release) capsules.
  Johnson F, Wagner G, Sun S, Stauffer J.
  
  Curr Med Res Opin. 2008 Jan;24(1):297-305.
  Pharmacokinetic profile of a 24-hour controlled-release OROS formulation of
  hydromorphone in the presence of alcohol.
  Sathyan G, Sivakumar K, Thipphawong J.
  
  Drug Dev Ind Pharm. 2007 Oct;33(10):1101-11.
  The effect of ethanol on the release of opioids from oral prolonged-release
  preparations.
  Walden M, Nicholls FA, Smith KJ, Tucker GT.
  --
  
  Regards,
  Sury
  

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