PharmPK Discussion - Estimate plasma concentration from non-compartmental variables

• On 12 Apr 2012 at 13:31:15, Warschkow Rene HCARE-KSSG-CHIR (Rene.Warschkow.-a-.kssg.ch) sent the message
  

  
  Dear PK List,
  
  We are a study group assessing tumor suppressive agents, but we have nobody with
  some knowlege about PK in our group.
  For our study we just need to know the plasma concentration of an agent, for
  which we retrieved mainly non-compartmental variables.
  Is there any formula to estimate the plasma concentration from the given
  variables, assuming that the agent was administered once at five consecutive
  days?
  dose is 15 mg/m**2
  Cmax 325
  Tmax 6
  C0 2123
  AUClast 9728
  AUCinf 9760
  T1/2 29
  CL 7054
  Vz 192
  Vss 942
  
  Thanks a lot for any appreciated help
  
  Rene Warschkow
  research coordinator
  department of surgery
  Kantonsspital St. Gallen
  Switzerland
  

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• On 13 Apr 2012 at 13:38:50, "Weiss, Markus" (markus.weiss.at.novartis.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi Rene,
  
  Is this IV dosing? Seems so.
  What concentration do you want, a daily average concentration or a concentration
  at a specific point in time?
  Average concentration is easy but the problem is that all your numbers lack
  units and it may be good to know the absolute dose for a plausibility check.
  Also the AUC of one dosing interval would be good to have, it is not clear if
  this was e.g. the last dose and sampling was for more than 24 h, in this case
  your AUCinf is not the dosing interval AUC.
  For concentration at any point in time you would need a model or at least assume
  a model. But maybe you can just read this concentration from your empirical
  concentration time curve?
  If you want a free concentration you need protein binding data of your compound.
  So basically it needs some more information.
  
  Markus
  

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• On 13 Apr 2012 at 11:00:44, "David S. Farrier" (DFarrier.aaa.SummitPK.com) sent the message
  

  
  Dear Rene,
  
  PK Solutions is our top-ranked, Excel-based pharmacokinetics data analysis
  software and may have a solution for you.
  
  PK Solutions has a unique feature for reconstructing the original plasma level
  curve and the complete suite of pk parameters from the intercept and rate values
  of up to a three term polyexponential distribution equation.
  
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  www.SummitPK.com/tools/tools.htm
  
  This free, Excel-based pk equations graphing demo provides a functioning example
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  adjustment of the six input variables found in the equation to view their effect
  on the curve, as well as on a corresponding set of related AUC results.
  
  I hope this is will be helpful for your objective.
  
  Regards,
  
  David S. Farrier, Ph.D.
  Summit Research Services
  68911 Open Field Dr.             Email:   DFarrier.aaa.SummitPK.com
  Montrose, CO 81401               Web:      http://www.SummitPK.com
  

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