PharmPK Discussion - Half-life of Ivermectin

• On 31 Jan 2012 at 23:55:22, "Mauricio" (rmsampaio.aaa.terra.com.br) sent the message
  

  
  Dear,
  
  I would like to know if are there pharmacokinetics or bioequivalencies
  studies, in humans, with long half-life for Ivermectin tablets?
  
  The half-life described in Micromedex is 18 hours. However, the maximum
  half-life described in Korolkovas is 56 hours. Is it the maximum or are
  there more data upper 56 h?
  
  

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• On 1 Feb 2012 at 10:11:52, Ravi Bhatia (pharmarkb.at.gmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Dear Mauricio
  
  In this case you can refer to innovater's NDA submitted to FDA. I
  believe that most accurate estimation is near to 18 hr (range: 16-22
  hr).
  There may be some outliers when half lives can be more than that of
  estimated population half-life. A general approach used in these cases
  is to use maximum stretched washout period based on half life.
  
  Please refer to
  CENTER FOR DRUG EVALUATION AND RESEARCH
  APPROVAL PACKAGE for: Ivermectin
  APPLICATION NUMBER: 050742
  
  I accept the correction from group if I have missed somrthing.
  Kind Regards
  
  [Try http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Label_ApprovalHistory#apphist
  - db]
  

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• On 2 Feb 2012 at 10:33:16, "DR.GUNA SAKARAN" (drgunasakaran.at.gmail.com) sent the message
  

  
  Dear Mr.Mauricio,
  
  Kindly go through the following article which gives you the details
  regarding Half life of Ivermectin tabelts.
  
  Aranzazu Gonzalez Canga, Ana M. Sahagun Prieto, M. Jose Diez Liebana,
  Nelida Fernandez Martinez, Matilde Sierra Vega, and Juan J. Garcia
  Vieitez. The Pharmacokinetics and Interactions of Ivermectin in Humans--A
  Mini-review. AAPS J. 2008 March; 10(1): 42-46. Published online 2008
  January 25. doi:  10.1208/s12248-007-9000-9
  
  The full article can be accessed from the following link
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751445/
  
  Regards,
  Dr.S.Gunasakaran, MD
  Head - Clinical Research & Medical Affairs,
  Azidus Laboratories Ltd, CRO.
  Clinical Research Forum http://www.clinicalresearchsociety.org/forum/
  
  

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