PharmPK Discussion - Intravenous P-gp or CYP inhibitor affecting first pass of an Oral P-gp or CYP3A4

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On 17 Apr 2012 at 15:34:22, (mdkzone.-at-.aol.com) sent the message

substrate

All:
   Does anyone know of a DDI case where an intravenously dosed P-gp or CYP
inhibitor has altered the bioavailability of an orally administered P-gp or CYP
substrate, clinically?  I'm specifically looking for an effect on first pass,
not systemic clearance.

Regards,
Michael

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