PharmPK Discussion - List of Preferred Vehicles

• On 3 Oct 2012 at 19:42:10, Jaclyn Stevens (jaclyn.d.stevens.-at-.gsk.com) sent the message
  

  
  Hello-
  =20
  My question is if anyone has a standard list of vehicles to use for Oral =
  and/or
  IV dosing in a preferred order.
  I would like to compare to my list- and update where I find necessary.
  Thank you
  =20
  Jaclyn Stevens
  Drug Dispensary -UM
  Formulation Scientist=
  
  

  Back to the Top

• On 4 Oct 2012 at 09:44:38, Ashok kumar Meena (ashok_meena.aaa.jubilantbiosys.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi Jaclyn Stevens,
  The selection of the formulation for NCE molecule is depend on the
  physicochemical properties so there is no standard list of excipients but we
  need to have a planed strategy for excipients selection . For oral drug delivery
  we need to follow following path way
  
  1. Suspension formulation by using suspending agents like Methyl cellulose, HEC
  HPMC low mol weight etc
  2. If we could not achieve the desire results we need to go for another approach
  like co solvent solubilization
  3. Addition of surfactants
  4. Addition of co solvent and surfactant
  5. Adjusting the pH of the formulation
  6. Advance formulation like SMEDDS and nanosuspension, nanocrystals formulation
  etc
  
  And in case of IV formulation we need to see the solubility of the compound in
  various suitable vehicles than we need to select following order
  1. Aqueous based solution formulation
  2. Co-solvent
  3. Surfactant
  4. pH adjustment
  
  The total quantity of excipients used in formulation is decided on the basis of
  the IIG limit (US FDA data base), in house data or published literature.
  
  If you need any more clarification I will happy to help you
  Regards
  Ashok Kumar Meena
  --
  Ashok Kumar Meena
  Pharmaceutical Development, Jubilant drug discovery center, #96, Industrial
  Suburb, 2nd Stage, Yeshwanthpur
  Bangalore-560022
  

  Back to the Top

• On 4 Oct 2012 at 22:22:57, Prashant Musmade (pmusmade.at.gmail.com) sent the message
  

  
  Dear Jaclyn
  Hope followoing articles may be useful for you.
  
  1.      Lee YC, Zocharski PD, Samas B. An intravenous formulation decision tree
  for discovery compound formulation development. Int J Pharm. 2003 Mar
  6;253(1-2):111-9.
  2.      Bittner B, Mountfield RJ. Intravenous administration of poorly soluble
  new drug entities in early drug discovery: the potential impact of formulation
  on pharmacokinetic parameters. Curr Opin Drug Discov Devel. 2002 Jan;5(1):59-71.
  Review.
  Regards
  PRASHANT
  
  

  Back to the Top

Copyright 1995-2011 David W. A. Bourne (david@boomer.org)