PharmPK Discussion - Lymph flow to the tissues

• On 6 Mar 2012 at 12:47:37, =?iso-8859-1?Q?Mar=EDa_Matoses_Osborne?= (mmatoses.-at-.alumni.unav.es) sent the message
  

  
  Dear PK experts,
  
  We are in the process of building a PBPK model for a new delivery system
  (nanoparticle) that travels to the tissues bound to the macrophages
  through the lymph.
  
  We have done a deep search in the literature looking for some
  information referent to lymph flow to the tissues in rats and humans.
  But we did not succeed on it.
  
  Could anyone of you please help us to find some information about it?c
  
  Thanks in advance,
  
  Maria Matoses-Osborne
  
  

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• On 6 Mar 2012 at 08:52:37, chaturvedula ayyappa (ayyappach.-at-.yahoo.com) sent the message
  

  
  Maria,
  
  The software BioDMET by GE is a PBPK modeling simulation software
  including lymph flow.  Their publication and user manual will be very
  useful for you.
  Website: http://pdsl.research.ge.com/BioDMET/
  
  J Pharmacokinet Pharmacodyn. 2012 Feb;39(1):37-54. Epub 2011 Dec 10.
  BioDMET: a physiologically based pharmacokinetic simulation tool for
  assessing proposed solutions to complex biological problems. Graf JF,
  Scholz BJ, Zavodszky MI.
  
  Regards,
  Ayyappa
  
  

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• On 7 Mar 2012 at 16:39:13, =?iso-8859-1?Q?Mar=EDa_Matoses_Osborne?= (mmatoses.at.alumni.unav.es) sent the message
  

  
  Dear Ayyappa,
  
  I have downloaded the software and tried it, but I don't think that's
  what I am looking for. It includes as lymphatic system the lymph nodes
  and spleen, but it doesn't include the lymph flows as well as the blood
  flows. And I am pretty sure that lymph flow reaches every organ in the
  body, mainly lymph nodes and spleen, but all of them. So I am looking
  for the lymph flow to all organs, and whether they are similar or not.
  
  Anyway, thanks for your advice I will keep searching for the answer, if
  there is any,
  
  Kind regards,
  
  Maria
  
  

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• On 7 Mar 2012 at 11:06:25, chaturvedula ayyappa (ayyappach.-at-.yahoo.com) sent the message
  

  
  Dear Maria,
  
  The paper "Physiologically-based pharmacokinetic (PBPK) model to
  predict IgG tissue kinetics in wild-type and FcRn-knockout mice Journal
  of Pharmacokinetics and Pharmacodynamics Volume 34, Number 5, 687-709"
  uses the PBPK model considering both plasma and lymph flows.  However,
  they assume lymphatic flow rates for visceral and nonvisceral organs
  were set to be 2 and 4% of the plasma flow rates, respectively.  Hope
  this helps along with following reference.
  
  Covell DG, Barbet J, Holton OD, Black CD, Parker RJ, Weinstein JN (1986)
  Pharmacokinetics of
  monoclonal immunoglobulin G1, F(ab')2, and Fab' in mice. Cancer Res
  46:3969-3978
   Regards,
  Ayyappa
  
  

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• On 9 Mar 2012 at 03:00:19, "Ed P'Connor" (efoconnor.aaa.gmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  May be better stated as lymph flow from the tissues
  
  

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• On 9 Mar 2012 at 03:02:37, "Ed P'Connor" (efoconnor.at.gmail.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Why would the term functional be used to
  Modify Cmax or any other pk param?
  
  

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