PharmPK Discussion - Mechanism of higher dose normalized AUC and oral CL at lower dosage

• On 13 Jun 2012 at 07:40:27, "Xu, Claire" (smartxucong.at.gmail.com) sent the message
  

  
  Hi, everyone, I am working on a compound given as 10mg and 60mg single dose orally. I
  found that both the dose normalized AUC and oral CL are higher at 10mg dose. I think there
  is some non linearity going on. I am trying to model the PK data now, can someone discuss
  about the possible mechanisms of higher dose normalized AUC and oral CL at lower dosage?
  Thanks a lot!
  
  --
  Xu, Claire
  

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• On 14 Jun 2012 at 03:50:30, wangchangguang (chg-wang.at.hotmail.com) sent the message
  

  
  Xu,
  
  you can collect some fecal samples to see if the drug are well absorbed at 60mg.kg before
  calculating PK parameters.
  
  changguang
  
  Department of Biochemistry
  UT Southwestern Medical Center
  5323 Harry Hines Boulevard
  Dallas, Texas
  

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