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In order to check the inhibition of CYP 3A4 in vivo, I am planning a =
study with
Midazolam as probe compound. I have several doubts in the design of the =
study.=20
As the intended route of the drug is neither PO or IV, but there is =
biliary=20
excretion . I am thinking to do the clinical trial only PO =
administration of
midazolam, Is all right? I am going to analyze parent Midazolam And the
question is important to analyze 1OH -Midazolam?
Thanks=
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