PharmPK Discussion - Polynomial UIR function

• On 21 May 2012 at 14:20:21, Harish Kaushik Kotakonda (kaushikkotakonda.aaa.gmail.com) sent the message
  

  
  Hello,
  I am novice in the field of IVIVC and Iam trying to understand the background of
  using Polynomial UIR function for deconvolution from PO &IV Bolus data.
  What is the significance of increasing exponentials from 2(bi),3(tri),...etc for
  predicting the absorption profile of the drug
  
  Can any body explain me
  
  Regards
  Kaushik
  

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• On 21 May 2012 at 21:17:25, "Charlie Brindley " (charlie.brindley.-a-.kinetassist.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  Hi Kaushik,
  
  I don't know about polynomial functions, but for fitting exponentials,
  typically to the weighting (IV data), you should select the appropriate
  model (e.g. bi-, tri) using statistical criteria (i.e. lowest AIC, minimise
  CV of parameter estimate, view observed vs. predicted data, partial
  derivatives etc.).
  
  If you are using deconvolution in WinNonlin, the oral data does not need to
  be fitted and help is online regarding appropriate selection of models.
  
  Charlie
  
  

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