PharmPK Discussion - Post-dosing period prior to feeding in BE study

• On 1 Feb 2012 at 11:47:46, Ruby Mosher (mosherru.at.k-state.edu) sent the message
  

  
  The following message was posted to: PharmPK
  
  In a bioequivalence study with an oral drug in suspension, if an animal
  has been fasted (10h) prior to dosing, is there an accepted period of
  time to continue fasting animals post-dosing?  (The label of the
  reference product indicates that Cmax is reached in approx 3h
  post-dosing in fasted animals).
  
  I've read "4h" as a suggested post-dose fasting time in humans, but is
  there a recommended post-dosing continuation of the fast for dogs and
  cats?  The absorption of this particular product  isn't affected by the
  presence of food, but I'm thinking that the variation in absorption will
  be less if the animals are not fed for at least an hour after dosing.
  There is not a label indication for dosing in the fasted or non-fasted
  state.
  
  Any advice or "correction of my thinking" would be greatly appreciated,
  
  Thanks,
  Ruby
  
  

  Back to the Top

Copyright 1995-2011 David W. A. Bourne (david@boomer.org)