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In a bioequivalence study with an oral drug in suspension, if an animal
has been fasted (10h) prior to dosing, is there an accepted period of
time to continue fasting animals post-dosing? (The label of the
reference product indicates that Cmax is reached in approx 3h
post-dosing in fasted animals).
I've read "4h" as a suggested post-dose fasting time in humans, but is
there a recommended post-dosing continuation of the fast for dogs and
cats? The absorption of this particular product isn't affected by the
presence of food, but I'm thinking that the variation in absorption will
be less if the animals are not fed for at least an hour after dosing.
There is not a label indication for dosing in the fasted or non-fasted
Any advice or "correction of my thinking" would be greatly appreciated,
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