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Dear All:
If a compound PK profile fit three compartment model well, and we know
the extrapolated intercept of A, B, C and 1st order rate constant of a,
b, c, does anyone know how to calculate K12, K21, K13 and K31? And for
another question, is there any difference between the steady-state
volume of distribution calculated via compartment approach and
non-compartment approach? When we use composition mechanistic equation
to predict Vss, is it refer to non-compartment calculated Vss or
compartment model calculated Vss? Thanks!
Jian
[Maybe this page will help. http://www.boomer.org/c/p4/c02/c07/c0707.html
You will need to do a cubic solution at some point. - search the archive as I
now remember someone posting some spreadsheets to solve this problem - db]
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The following message was posted to: PharmPK
hi Jian,
regarding macro-micro for three compartments, this is probably the
reference you are looking for:
Richard N. Upton, Calculating the hybrid (macro) rate constants of a
three-compartment mamillary pharmacokinetic model from known
micro-rate constants
Journal of Pharmacological and Toxicological Methods 49 (2004) 65-68
Cheers. Maciej
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