PharmPK Discussion - Variability in PK profile of NCEs by SC route of administration

• On 29 Aug 2012 at 20:06:57, Praveen Kumar (bogapraveen.-a-.gmail.com) sent the message
  

  
  Dear All,
  
  I would like know the PK profile of subcutaneous administration of NCEs in
  Rodents,particularly in jugular vein cannulated rats.
  Is there any chances to observe variability in PK profile (like variation in
  Tmax,Cmax,Kel etc) within in rats due to improper administration by SC.
  
  Kindly give your valuable suggestions.
  
  Thank you in advance.
  
  Regards
  Praveen
  
  

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• On 29 Aug 2012 at 13:41:35, "Huebert, Norman D. [JRDUS]" (NHUEBERT.aaa.its.jnj.com) sent the message
  

  
  The following message was posted to: PharmPK
  
  It is always possible to observe variability due to poor technique.
  Variabiity may also arise from such factors as solubility in the sc
  formulation.  Generally though, we see much tighter results sc than by
  po or ip administration.
  
  Norman D. Huebert
  ADME Team leader
  41-3130
  Janssen R&D, LLC
  Welsh and McKean Roads
  PO Box 776
  Spring House, PA 19477
  U.S.A.
  
  

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• On 31 Aug 2012 at 17:14:19, Stefano Porzio (stefano.porzio.at.alice.it) sent the message
  

  
  The following message was posted to: PharmPK
  
  Also my experience supports the statements of Norman Huebert: variability
  after sc. dosing is always expected less than po or ip formulation, if not,
  factors affecting the release of solution from injection site have to be
  considered (poor solubility, inappropriate injection technique, etc.).
  
  Stefano Porzio
  
  

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