PharmPK Discussion - BACs after drinking beer, wine and spirits

• On 5 May 2014 at 16:31:24, Peter W Mullen (pmullen.-at-.kemic.com) sent the message
  

  
  Hi PharmPkers,
  
  Since I know that a number of you "imbibe" occasionally :-) , I thought that you might find the
  recent paper at the following link of interest:
  http://onlinelibrary.wiley.com/doi/10.1111/acer.12355/pdf
  
  There's really not much new in this study in terms of the differences in BAC resulting from
  consuming different types of alcoholic beverages.  I'd be interested, however, in responses from
  "experts" on this list re. the noncompartmental pk analysis undertaken, especially re. the
  calculation (and meaning) of MRT and Vss given that alcohol has nonlinear elimination kinetics.
  
  Also, given alcohol's oral administration, wouldn't AUMC/AUC = MRT + MAT (not just MRT)?
  
  Regards,
  Peter
  
  Peter W. Mullen, PhD, FCSFS
  KEMIC BIORESEARCH
  P.O. Box 878
  Kentville
  Nova Scotia, B4N 4H8
  Canada
  
  E-mail  pmullen.at.kemic.com
  
  

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• On 7 May 2014 at 10:46:01, William Wolowich (wwolowic.aaa.nova.edu) sent the message
  

  
  The authors also calculated relative bioavailability using the AUC ratio method, which assumes
  linear and stationery clearance, neither of which is true for etoh. I suspect upon further analysis,
  a letter to the editor will be needed.
  Bill
  
  William R. Wolowich, Pharm.D., R.Ph.
  Department of Pharmacy Practice
  College of Pharmacy
  Nova Southeastern Universtiy
  Ft. Lauderdale, FL. USA
  
  

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• On 19 May 2014 at 12:38:17, Peter W Mullen (pmullen.at.kemic.com) sent the message
  

  
  Hi Bill,
  
  Thanks. I certainly agree with your comments.
  
  I'm somewhat surprised that there's been no response from other PharmPk
  list members, given the topic of the paper and the PK analysis described
  therein.
  
  - Peter
  
  

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