PharmPK Discussion - BCS of Clonixin

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On 7 Mar 2014 at 13:47:42, rmsampaio2002.-at-.yahoo.com.br sent the message


I am looking for any information about BCS of Clonixin ( used as its lysine salt).
Does anybody have an information about it?

Regards!

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On 7 Mar 2014 at 14:32:19, Ving Lee (VLee.-at-.adesisinc.com) sent the message
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Class II

V. Lee
Adesis Inc.
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On 9 Mar 2014 at 11:24:04, Maurício (rmsampaio2002.-a-.yahoo.com.br) sent the message


Dear Lee,
I agree with you! But, do you have an article ou other reference available to suport this
information?
Regards

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On 9 Mar 2014 at 18:34:28, Ving Lee (VLee.-a-.adesisinc.com) sent the message


If one reads between the lines of the following two articles, you will come to the conclusion
clonixin is a Class II BCS Classification..

1) Metabolism and pharmacokinetics of a new nonsteroid, anti-inflammatory agent,
2-(3-chloro-o-toluidino) nicotinic acid (clonixin) in rats, dogs and monkeys.

B Katchen, S Buxbaum, J Meyer, J Ning, Journal of Pharmacology and Experimental Therapeutics,
184(2):453-64 (1973).

2) The "high solubility" definition of the current FDA Guidance on Biopharmaceutical Classification
System may be too strict for acidic drugs.

Mehran Yazdanian, Katherine Briggs, Corinne Jankovsky, Amale Hawi, Pharmaceutical Research;
21(2):293-9 (2004).

Regards,
V. Lee

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