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Dear Jian
Rodents do not have Cortisol. They do have Corticosterone. We in Pfizer have measured it in rats and
mice and the concentration in serum is 0.032 +/- 0.010 uM.
Anup
Anup Zutshi Ph.D.
Pharmacokinetics, Dynamics and Metabolism
PGRD, Pfizer Andover/Cambridge Laboratories
200 Cambridge Park Drive. Room T-6011
Cambridge, MA - 02141
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The problem with corticosterone measurements in rodents was that as soon as you handled the animals
the levels would spike. We had tried to measure the basal levels even with remote sampling using the
Culex sampling system. The clicking noise of the machinery made the results spike. As stated in the
earlier email we measured an average concentration of 0.032 +/- 0.010 uM in rodent serum
Anup
Anup Zutshi Ph.D.
Pharmacokinetics, Dynamics and Metabolism
PGRD, Pfizer Andover/Cambridge Laboratories
200 Cambridge Park Drive. Room T-6011
Cambridge, MA - 02141
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