PharmPK Discussion - Drug in breast milk pharmacokinetics

• On 24 Mar 2014 at 19:09:31, Nisak33 (nisak33.aaa.yahoo.com) sent the message
  

  
  dear all,
  
  does anyone have an experience in estimating pk of drugs in breastmilk, the guideline of research
  when conducted in human, and i would like to have the most cited references. thank you in advanced.
  
  khoirotin nisak, B.Pharm. Apt.
  master of pharmacy candidate,
  Airlangga university, Indonesia
  
  

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• On 25 Mar 2014 at 08:35:29, Jzb (jbyczkowski.at.netscape.net) sent the message
  

  
  What exactly are you asking for - estimate of pKa in breast milk, or estimate of PharmacoKinetics
  (lactational transfer) in breast milk?
  
  Best wishes.
               Janusz Z. Byczkowski, Ph.D.,D.Sc.
  
  

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• On 25 Mar 2014 at 09:34:28, Sherwin K Sy (sherwin.kenneth.sy.aaa.gmail.com) sent the message
  

  
  We had done sparse sampling study design to assess the transfer of
  tramadol and its O-desmethyl metabolite into transitional breast milk,
  as well as model it. Professor Kenneth Ilett from the University of
  Western Australia had done a lot of work in this area. I have listed
  the two references that I mentioned below.
  
  Ilett KF, Paech MJ, Page-Sharp M, Sy SKB, Kristensen JH, Goy R, Chua
  S, Christmas T, Scott KL. Use of a sparse sampling study design to
  assess transfer of tramadol and its O-desmethyl metabolite into
  transitional breast milk. Br J Clin Pharmacol 2008;65:661-6.
  
  Salman S, Sy SKB, Ilett, KF, Page-Sharp M, Paech MJ. Population
  pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in
  plasma and breast milk. Eur J Clin Pharmacol 2011; 67:899-908.
  
  Best wishes,
  Sherwin Sy
  
  

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• On 25 Mar 2014 at 11:44:58, Tarra knotts (tt1_chemistry.at.hotmail.com) sent the message
  

  
  Thomas W. Hale  runs infantrisk.com would be a very good go-to for this information on many drugs.
  Often the studies aren't great (limited subjects, limited time points) but better than nothing. Keep
  in mind that the amount found in milk at the beginning of a session and the amount at the end of the
  session may vary due to fat content and, I would assume, time to equilibrium.
  
  

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• On 26 Mar 2014 at 09:01:34, David Bourne (david.-at-.BOOMER.ORG) sent the message
  

  
  Thank you for the information, actually i want to learn about the absolute dosage an infant will
  receive from his/her mother's milk. bu I am not sure about the analysis methods or sampling time.
  
  very best regards,
  
  Khoirotin Nisak
  khoirotin nisak 
  
  --
  http://www.motherisk.org/women/breastfeeding.jsp
  
  (Toronto Hospital for Sick Children)
  William Wolowich 
  
  

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Copyright 1995-2014 David W. A. Bourne (david@boomer.org)