PharmPK Discussion - Estimation of the absorption rate constant

• On 4 Apr 2014 at 13:02:12, Chris Kemper (chris_kemper.at.pharmanavigatorsllc.com) sent the message
  

  
  Is it possible to use a non-compartmental approach to estimate ka, the absorption rate constant,
  with only oral data.
  
  Christopher J. Kemper, Ph.D.
  Pharma Navigators, LLC
  Chris_kemper.-at-.pharmanavigatorsllc.com
  
  [See http://www.boomer.org/c/p4/c09/c0904.html ;-)
  Ref: Swintosky, J.V., Dittert, L.W. and Doluisio, J.T. 1969 Estimation of drug absorption rates from
  blood concentration profiles, Amer. J. Hospital Pharmacy, 26 (Sept), 519-522
  Also, if you know ka >> kel (or kel >> ka), the ratio is greater than 5 the method residuals can be
  used
  See http://www.boomer.org/c/p4/c09/c0902.html - db]
  
  

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• On 4 Apr 2014 at 13:17:31, (dale.sharp.aaa.boehringer-ingelheim.com) sent the message
  

  
  Chris,
  
  Ka = 1/MAT, where MAT = MRTpo-MRTiv.
  
  Dale E. Sharp, Ph.D., DABT
  Senior Principal Scientist, DMPK
  Boehringer-Ingelheim Pharmaceuticals Inc.
  
  [Dale, no iv data :-( but if you know kel and one compartment PK (sorry not non compartmental ;-),
  maybe MRTiv = 1/kel or you could use the Wagner-Nelson method
  See http://www.boomer.org/c/p4/c09/c0903.html - db]
  
  

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• On 5 Apr 2014 at 08:59:15, Ayyappa Chaturvedula (ayyappach.aaa.yahoo.com) sent the message
  

  
  Wagner-Nelson method for one compartment model drugs is a useful method. You may refer the chapter
  quantitation of drug absorption in the book Applied pharmacokinetics and biopharmaceutics by Shargel
  and Yu.
  
  Regards,
  Ayyappa
  
  

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