PharmPK Discussion - Hepatocellularity in pig

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On 13 Jan 2014 at 16:04:34, Thuy.T.Tran.at.gsk.com sent the message


Has anyone determined value for hepatocellularity in pig or come across a publication with this
value?

Thank you so much for your help.

Thuy Tran
Investigator
Modeling & Translational Biology
DMPK
R&D Platform Technology & Science

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On 14 Jan 2014 at 12:10:25, LD ADME Consult (ld.-a-.admeconsult.com) sent the message


Dear Thuy Tran,

it is found in the following work:
Sjögren, E., Bredberg, U., & Lennernäs, H. (2012). The pharmacokinetics and hepatic disposition of
repaglinide in pigs: mechanistic modeling of metabolism and transport. Molecular pharmaceutics,
9(4), 823–41. doi:10.1021/mp200218p

Estimated to be 120 x 10 E6 cells /g liver

kind regards

Lars

--
Lars Dalgaard
LD ADME Consult
www.admeconsult.com

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