PharmPK Discussion - In vitro metabolism of cytarabine

• On 24 Feb 2014 at 11:52:45, charlie.brindley.-at-.kinetassist.com sent the message
  

  
  Does anyone know of information on in vitro metabolism of cytarabine?
  
  There is evidence that cytarabine undergoes deamination in the liver, but I was looking for specific
  conditions for microsomal metabolism.
  
  Charlie Brindley
  
  

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• On 24 Feb 2014 at 15:00:37, Carol Collins (carolc3.-at-.uw.edu) sent the message
  

  
  Cytarabine is a prodrug. It is transported intracellularly by ENT1 and phosphorylated by
  deoxycytidine kinase and then by nucleotide kinases to cytosine arabinoside triphosphate. This
  compound is inactivated by cytidine deaminase and then dephosphorylated.
  
  

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• On 25 Feb 2014 at 09:44:02, Tarra knotts (tt1_chemistry.-a-.hotmail.com) sent the message
  

  
  cytosols and S9s may have some CD activity: http://www.ncbi.nlm.nih.gov/pubmed/21804305.  Plasma
  definitely has to be stabilized.
  its not a P450 metabolism but you might see some metabolism in the incubations.
  
  

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Copyright 1995-2014 David W. A. Bourne (david@boomer.org)