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I have a compound, the exposure in rat plasma was low, Cmax after oral dose of 1 mg/kg is around 20
ng/mL, the excretion in urine, feces and bile was very
low within 24 hr post dose, less than 5%. And we also ran a rat tissue distribution study, the
exposure in tissues is widely distributed and the
concentrations in some tissues are higher than 100 fold than plasma.
Is the profile of the compound in rat reasonable? For the low excretion, should I prolong the test
time to 48 hr or longer? Is there any mistake in samples
bioanalysis can result in the low excretion?
Many thanks for your time.
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