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I want to perform metabolism studies for 2 compounds ( curcumin and Dimethoxy curcumin) in order to
compare between their intrinsic clearence.
I have done the experiment several times and in each time the intrinsic clearence of
dimethoxycurcumin is higher than curcumin which is opposite to literature.
I found that the wrong in my procedure that i was subjecting them both only to Phase I metabolism
which is not the true case invivo; so i think i have to include Phase II metabolism by the use of (
Uridine 5'-diphosphoglucuronic Acid Trisodium) which is important in gluronidation but i don't know
whether i have to include phase I and II together in the same step and if so, what will be the
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