PharmPK Discussion - P-glycoprotein

• On 26 Mar 2014 at 18:23:26, pharmacokinetician Young (pharmacokinetician.at.GMAIL.COM) sent the message
  

  
  Hi all,
  How one interpret the data from P-gp chemical knockout model? To be precise
  based on the fold change in brain to plasma ratio, how do you classify the
  compounds as poor, moderate or good Pgp substrate in this model? Any
  literature reference in this regard would be highly appreciated and finally
  how reliable chemical knockout data in comparison to genetic models?
  Regards
  Young
  
  

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• On 27 Mar 2014 at 15:07:01, Shoaf, Susan (Susan.Shoaf.aaa.otsuka-us.com) sent the message
  

  
  At the recent ASCPT meeting, J Polli gave a talk entitled Efflux Transporters in the Blood
  Brain Barrier: Why Clinically Relevent Drug Interactions are Unlikely
  
  You might try looking for some of his publications.
  
  Susan
  
  

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