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Dear All,
It is well established that FcRn plays role in mAB Pk via salvaging it from degradation. In this
context, PK of therapeutic antibodies are always investigated in murine model considering murine
FcRn bind human IgG more efficiently than other species and thus could be a species of choice for PK
investigations of therapeutic antibody as against non human primates are considered to be a relevant
species for safety assessment of therapeutic antibodies.
Thus PK assessment of monoclonal antibodies in murine model should be done in preclinical studies
considering mice as species of choice in the PK studies?
Best regards,
Vishal.
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