PharmPK Discussion - Renal CL of carboxylic acids in dogs

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On 20 Nov 2014 at 13:08:32, charlie.brindley.-at-.kinetassist.com sent the message


Is anyone aware of issues with renal clearance of a carboxylic acid in dogs?

Thanks,

Charlie Brindley

[Urine pH, renal reabsorption - db]

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On 21 Nov 2014 at 11:28:16, McCoy, Alene (AMcCoy.-a-.dow.com) sent the message


Hi Charlie,

This reference may be useful to you:

Timchalk, N., (2004), Comparative Inter-Species Pharmokinetics of Phenoxyacetic Acid Herbicides and
Related Organic Acids , Evidence that Dog is not a Relevant Species for Evaluation of Human Health
Risk. Toxicology, 200, 1-19.

Best Regards,
Alene McCoy

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