PharmPK Discussion - Smooth in bioanalysis

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On 5 Jun 2014 at 08:50:46, Paras.shah.-a-.veedacr.com sent the message


Can we use different smooth values for drug and ISTD ?

EX. For DRUG- Smooth kept 4 and ISTD-Smooth kept 3

Thanks and Regards,
Paras Shah
Jr. Auditor - Quality Assurance
Veeda Clinical Research Pvt. Ltd.
Shivalik Plaza - A, Near IIM, Ambawadi
Ahmedabad - 380015, Gujarat, India

[Took me awhile to realize what the question was here. Smooth as in time constant for the signal
filter or similar? Given that modern controllers allow all sort of parameter changes, adjusting
smoothing should be possible. You would need to properly evaluate and include in SOPs?? - db]

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On 5 Jun 2014 at 11:01:12, sudipta basu (basu.sudipta.-at-.gmail.com) sent the message
```
Yes.
Thanks and regards,
S.Basu
As so. Director
Dr. Reddy's Lab
```
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On 6 Jun 2014 at 10:30:25, Kintan Patel (kvpatel1907.-at-.gmail.com) sent the message


Yes we can use different smooth value for drug and istd but we have to keep integration parameter
same through out MV and Study sample analysis if possible.

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On 6 Jun 2014 at 10:31:07, DIPAK S (dharwani.-at-.gmail.com) sent the message
```
Yes you can use. But for anvisa you have to keep value below 5.
Regards,
Dipak harwani
```
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