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I am sorry I missed this conversation previously but I wanted to confirm that the Nedelman method
mentioned by Charlie and Jie;
" Actually, it is possible to estimate variability from mean concentrations derived from a
destructive blood sampling study without using a mixed-effect model.
See Nedelman et al 1995, Pharm Res 12:124 which applies Bailer's method for obtaining confidence
intervals (and SEs) for AUC (when only one sample per subject but multiple subjects samples at
several sampling times)."
Is implemented in Phoenix WinNonlin (since version 5) and is simply accessed by checking the
"sparse" option in the NCA set up.
> Get tips and discuss Pharsight products with other users; www.pharsight.com/extranet
Alternatively with a standard license you can access Naïve pool as a population run with the raw
individual data which should give you a 'friendly' introduction to the capabilities of NLME which
many of our other users are excited to be able to perform quickly and easily within the pre-clinical
Best regards, Simon.
Senior Scientific Consultant
Pharsight- A Certara™ Company
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