PharmPK Discussion - Cmax of single dose from multiple dose steady state BE study

• On 17 Jul 2015 at 10:19:28, Narayanakumar R (narayanakumar.r.-a-.ETHICSBIOLAB.COM) sent the message
  

  
  Dear Colleague,
  
  Is it possible to calculate Cmax of single dose from multiple dose steady state bioequivalence study
  data from the literature?
  
  Regards
  Narayana Kumar.
  
  

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• On 17 Jul 2015 at 09:35:07, Parag Lunar (prgkmr.-at-.gmail.com) sent the message
  

  
  Yes, the relationship between pk parameters at steady state and after single dose is described by
  the accumulation factor equation:
  
  Conc SS = Conc SD * (1/(1-e^-kt))
  
  K = elimination rate constant
  T= dosing interval
  
  Parag
  
  

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• On 17 Jul 2015 at 14:27:00, William Wool which (wolowich.-a-.bellsouth.net) sent the message
  

  
  Yes it is called reverse superposition
  
  

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