PharmPK Discussion - Drug with renal clearance exceeding PAH clearance

• On 24 Sep 2015 at 08:16:26, Philip Kiser (pdk7.-a-.CASE.EDU) sent the message
  

  
  Hi Everyone,
  
  I was wondering if anyone knows of a drug whose renal clearance exceeds that of PAH. I guess the
  drug would have to be one that distributes to some extent into formed elements but can still be
  completely extracted from plasma and blood cells by active secretion processes. Obviously, it would
  have to be an exceptional case since the drug would likely have to be somewhat lipophilic to enter
  the blood cells and the lipophilicity would also tend to allow passive reabsorption, thus reducing
  its renal clearance. Thanks for your insights.
  
  Philip
  
  

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• On 24 Sep 2015 at 22:44:17, Carl Kirkpatrick (carl.kirkpatrick.-at-.monash.edu) sent the message
  

  	
  Hi Philip
  
  You could try looking here for possible options  Clin Pharmacokinet. 2003;42(14):1193-211.
  Principles and clinical application of assessing alterations in renal elimination pathways
  
  Best wishes
  
  Carl
  
  

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• On 30 Sep 2015 at 18:47:33, Philip Kiser (pdk7.-at-.case.edu) sent the message
  

  
  Hi Carl,
  
  Thanks a lot for pointing me to that reference. I searched through it but didn't see any examples of
  drug clearance values that exceed that of PAH.
  
  Best,
  
  Philip
  
  

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