PharmPK Discussion - Fatty food increase compound exposure

• On 6 Mar 2015 at 03:15:59, Yali Chen (ch103ch.aaa.yahoo.com) sent the message
  

  
  Dear all,
  I’d appreciate helps from the group on reference papers about known CYP 3A4 inhibitors in fatty
  food. We observed an increase of compound exposure in health volunteers fed with fatty food
  comparing to those regular meal-fed. Would there be other explanations to the observation as well?
  Many thanks in advance.
  Yali Chen
  ch103ch.-a-.yahoo.com
  
  

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• On 7 Mar 2015 at 15:02:29, azia_karim (azia_karim.aaa.yahoo.com) sent the message
  

  
  Fatty food results in production of increased bile and pancreatic fluid which promote dissolution of
  poorly soluble drugs. The net result is increased sbsorption. Fatty food also delays stomach
  emptying time there by prolonging the Tmax value. This is the most likely explanation of your
  findings.
  
  I hope this helps.
  
  Azzaro Karim
  
  

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• On 21 Mar 2015 at 09:31:49, hanliang0705 (hanliang0705.aaa.163.com) sent the message
  

  
  Fatty food results in production of increased bile and pancreastic fluid which increase the poorly
  soluble drugs entering lymphatic system. In turn, drugs in lymphatic system will be
  released/deliveried to blood. The net result is increased in systemic exposure.
  
  Thanks,
  Jack
  
  

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