PharmPK Discussion - Olanzapine metabolites

• On 3 Apr 2015 at 09:09:16, Remmerie, Bart (BREMMERI.at.its.jnj.com) sent the message
  

  
  Dear,
  To support evaluation of selectivity of an immunoassay, I’d like to solicit information on the
  (relative) abundance of the olanzapine metabolites.
  Although the mas balance study suggests that 80% of radioactivity is associated with metabolites,
  the abundance of well-documented metabolites (10-N-glucuronide, 4'-N-desmethyl olanzapine, N-oxide,
  ) does not fill the gap.
  Any information on other metabolites, e.g. 2-OH-methyl-olanzapine, 2-carboxy olanzapine,
  N-desmethyl-2-carboxy-olanzapine, 2-carboxy olanzapine glucuronide etc?
  
  Kind regards,
  Bart
  
  

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