PharmPK Discussion - PK Modeling

• On 6 May 2015 at 00:54:55, Joe DePasquale (jgdepasquale.-at-.GMAIL.COM) sent the message
  

  
  Hello,
  
  I was working on compartmental modeling and I was wondering what the clinical issues are for
  considering two compartmental model data/drug as one compartmental model data/drug.
  
  Thanks,
  Joe DePasquale
  
  

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• On 7 May 2015 at 13:27:40, Toufigh Gordi (tg.-a-.tgordi.com) sent the message
  

  
  Joe,
  
  There are no "clinical issues" with one or two compartment models. You
  have a set of data from your study and you are applying a mathematical
  model to describe the data. Your data dictates what model to choose,
  i.e., what model describes your data best. In other words, you don't
  choose a one or two compartment model based on "clinical issues", the
  data drives your choice of the model.
  
  Toufigh
  
  --
  Toufigh Gordi, PhD
  www.tgordi.com
  E-mail: tg.at.tgordi.com
  
  

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• On 8 May 2015 at 08:36:32, Dimiter Terziivanov (terziiv.at.yahoo.com) sent the message
  

  
  Joe,
  
  The issue you are interested in is discussed in details by John G. Wagner in 'Fundamentals of
  Clinical Pharmacokinetics', pp. 154-155, 2nd ed, 1975.
  
  We observed in clinical setting collapsing of 2-COM to 1-COM (Terziivanov,D. et al. Pharmacokinetics
  and quantitative characterization of Cefotiam excretion ways after i.v. administartion in patinets
  after cholecystectomy. Eur J Clin Pharmacol., 1986, 30, 439-444). In the paper we have described a
  patient with PK characteristics determining a 'collapse' of 2-COM to 1-COM. I hope it will be
  helpful to you.
  
  Greetings,
  
  Dimiter
  
  Dimiter Terziivanov, MD,PhD,DSc, Professor
  Head, Dept. of Pharmacology and Clinical Pharmacology
  SOFIA UNIVERSITY
  “ST. KLIMENT OHRIDSKI”
  FACULTY OF MEDICINE
  FACULTY OF CHEMISTRY AND PHARMACY
  UNIV HOSP "LOZENETZ"
  1 Koziak str.
  1407 Sofia, BULGARIA
  
  

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• On 8 May 2015 at 08:43:56, (Nathalie.Toublanc.aaa.ucb.com) sent the message
  

  
  Hi,
  
  One of the effect could be underestimation of the Cmax, which can be a problem if either safety or
  efficacy are deemed related to it.
  
  Best regards,
  
  Nathalie
  
  

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• On 13 May 2015 at 23:41:04, Joe DePasquale (jgdepasquale.-a-.gmail.com) sent the message
  

  
  Thank you all for the input. I know the data dictates the model, but I wanted to talk about the
  consequences or pitfalls of choosing a 1CM when a 2CM should have been used instead.
  Underestimation of the Cmax is very helpful and I will be sure to refer to the text mentioned as
  well.  All of your answers have been very helpful.  I appreciate the help!
  
  Thanks,
  Joe
  
  

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